Human Life Span Extension

Ketone bodies mimic the life span extending properties of caloric restriction.

 

Methionine restriction and life-span control.

 

Transcriptional and epigenetic regulation of autophagy in aging.

 

Vaccines in adults.

 

Experimental Models for Aging and their Potential for Novel Drug Discovery.

 

Lifespan and healthspan extension by resveratrol.

 

Sirtuin signaling in cellular senescence and aging.

 

Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis.

 

Autophagy and Longevity.

 

Growth Hormone Deficiency: Health and Longevity.

 

Fasting and rapamycin: diabetes versus benevolent glucose intolerance.

 

Autophagy as a promoter of longevity: insights from model organisms.

 

The GH/IGF-1 axis in ageing and longevity.

 

Essential role for autophagy in life span extension.

 

Genetics, life span, health span, and the aging process in Caenorhabditis elegans.

 

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation.

 

Growth Hormone and Aging: Updated Review.

 

Nonoperative treatment in lumbar spondylolysis and spondylolisthesis: a systematic review.

 

Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism.

 

The role of autophagy in the regulation of yeast life span.

 

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species.

 

Role of Myokines in Regulating Skeletal Muscle Mass and Function.

 

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.

 

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling.

 

The road ahead for health and lifespan interventions.

 

Life extension, human rights, and the rational refinement of repugnance.

 

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.

 

Molecular signatures of longevity: Insights from cross-species comparative studies.

 

An overview of the molecular mechanism of autophagy.

 

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.

 

Metformin and cognition from the perspectives of sex, age, and disease.

 

Senotherapeutics: emerging strategy for healthy aging and age-related disease.

 

Circadian rhythms, aging, and life span in mammals.

 

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging.

 

Mitochondrial longevity pathways.

 

Impact of Political Economy on Population Health: A Systematic Review of Reviews.

 

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.

 

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.

 

Caloric restriction: is mammalian life extension linked to p53?

 

How Much Should We Weigh for a Long and Healthy Life Span? The Need to Reconcile Caloric Restriction versus Longevity with Body Mass Index versus Mortality Data.

 

TOR on the brain.

 

Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans.

 

Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life.

 

The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.

 

Structural Biology of Proline Catabolic Enzymes.

 

Stem cells and anti-aging genes: double-edged sword-do the same job of life extension.

 

Ageing and eating.

 

Metformin: A Hopeful Promise in Aging Research.

 

A simple model system for age-dependent DNA damage and cancer.

 

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective.

Meninges in cancer imaging.

 

Is the clinical lipidomics a potential goldmine?

 

Four Principles Regarding an Effective Treatment of Aging.

 

Metformin for aging and cancer prevention.

 

Pleiotropic responses to methionine restriction.

 

Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.

 

In Search of Rationality in Human Longevity and Immortality.

 

Impact papers on aging in 2009.

 

Contributions of Health Care to Longevity: A Review of 4 Estimation Methods.

 

The role of sirtuins in modulating redox stressors.

 

Contemporary human genetic strategies in aging research.

 

The role of insulin/IGF-like signaling in C. elegans longevity and aging.

 

TOR-mediated regulation of metabolism in aging.

 

The paradox of mitochondrial dysfunction and extended longevity.

 

Mapping evidence on the burden and distribution of childhood obesity in sub-Saharan Africa: a scoping review protocol.

 

Longevity extension by phytochemicals.

 

The redox stress hypothesis of aging.

 

Links between growth hormone and aging.

 

Herpesvirus and Autophagy: "All Right, Everybody Be Cool, This Is a Robbery!".

 

The role of curcumin in aging and senescence: Molecular mechanisms.

 

GH and ageing: Pitfalls and new insights.

 

Dynamic DNA Methylation During Aging: A "Prophet" of Age-Related Outcomes.

 

Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle.

 

Effect of feeding regimens on circadian rhythms: implications for aging and longevity.

 

Comparative Approaches to Understanding the Relation Between Aging and Physical Function.

 

Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.

 

Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer's Disease.

 

Genome-environment interactions that modulate aging: powerful targets for drug discovery.

 

Drosophila Gut-A Nexus Between Dietary Restriction and Lifespan.

 

Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug?

 

Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease.

 

Mitochondrial uncoupling and lifespan.

 

The extended evolutionary synthesis and the role of soft inheritance in evolution.

 

Pharmacological lifespan extension of invertebrates.

 

SIRT3: as simple as it seems?

 

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands.

 

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.

 

How to live long and prosper: autophagy, mitochondria, and aging.

 

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.

 

Healthy aging: is smaller better? - a mini-review.

 

Regulation of longevity by the reproductive system.

 

Lifespan extension in genetically modified mice.

 

Reactive oxygen species, ageing and the hormesis police.

 

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.

 

Mitochondrial energy metabolism and ageing.

 

Does autophagy take a front seat in lifespan extension?

 

The TOR pathway comes of age.

 

Endocrine alterations in response to calorie restriction in humans.

 

Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research.

 

Can ageing be slowed?: Hormetic and redox perspectives.

 

Organ-specific mediation of lifespan extension: more than a gut feeling?

 

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives.

 

Healthspan and longevity can be extended by suppression of growth hormone signaling.

 

The fine line between lifespan extension and shortening in response to caloric restriction.

 

Epigenetic regulation of caloric restriction in aging.

 

Resveratrol, sirtuins, and the promise of a DR mimetic.

 

Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells?

 

The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?

 

THow diet interacts with longevity genes.

 

Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.

 

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes.

 

TOR and ageing: a complex pathway for a complex process.

 

The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.

 

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.

 

Aging and energetics' 'Top 40' future research opportunities 2010-2013.

 

Endocrine function in naturally long-living small mammals.

 

Modelling environmentally-mediated infectious diseases of humans: transmission dynamics of schistosomiasis in China.

 

Fixed-bearing unicompartmental knee arthroplasty. Patients' selection and operative technique.

 

Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae.

 

Advances in endocrinology of aging research, 2005-2006.

 

Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes.

 

The complexity of aging: are some aging processes more equal than others?

 

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.

 

Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?

 

How will telomeric complex be further contributed to our longevity? - the potential novel biomarkers of telomere complex counteracting both aging and cancer.

 

Sirtuin 1, stem cells, aging, and stem cell aging.

 

Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction.

 

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster.

 

 

Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes.

 

Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

 

Genetic potential of interfacial guided osteogenesis in implant devices.

 

Exploiting the rodent model for studies on the pharmacology of lifespan extension.

 

Assessing the quality of healthcare provided to children.