Methionine Restriction For  Longevity & Cancer Therapy

Methionine restriction and life-span control.


Methionine Restriction and Cancer Biology.


Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.


Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species.


Molecular signatures of longevity: Insights from cross-species comparative studies.


HNF4alpha regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.


Pleiotropic responses to methionine restriction.


Dietary methionine influences therapy in mouse cancer models and alters human metabolism.


Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?


Methionine restriction fundamentally supports health by tightening epithelial barriers.


Methionine restriction prevents onset of type 2 diabetes in NZO mice.


Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype.


Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome.


Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects.


Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats.


Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights.


Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.


Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action.


FGF21, not GCN2, influences bone morphology due to dietary protein restrictions.


Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response.


Sexually Dimorphic Effects of Dietary Methionine Restriction are Dependent on Age when the Diet is Introduced.


Preoperative Protein or Methionine Restriction Preserves Wound Healing and Reduces Hyperglycemia.


Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.


Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast.


Effects of dietary methionine restriction on postnatal growth, insulin sensitivity, and glucose metabolism in intrauterine growth retardation pigs at 49 and 105 d of age.


Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent.


Dietary methionine restriction attenuates renal ischaemia/reperfusion-induced myocardial injury by activating the CSE/H2S/ERS pathway in diabetic mice.


Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.


Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.


Effect of Methionine Restriction on Bone Density and NK Cell Activity.


Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.


Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.


Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.


Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.


The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats.


S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.


Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging.


Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status.


Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial.


Dietary methionine restriction: Effects on glucose tolerance, lipid content and micro-RNA composition in the muscle of rainbow trout.


The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction.


Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy.


Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling.


An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice.


Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.


Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.


Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.


Methionine restriction slows down senescence in human diploid fibroblasts.


Increased transsulfuration mediates longevity and dietary restriction in Drosophila.


Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice.


Weight Loss and Concomitant Adipose Autophagy in Methionine-Restricted Obese Mice is Not Dependent on Adiponectin or FGF21.


 Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells.


Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction.


Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction.


Differential effects of specific amino acid restriction on glucose metabolism, reduction/oxidation status and mitochondrial damage in DU145 and PC3 prostate cancer cells.


The impact of dietary methionine restriction on biomarkers of metabolic health.


A global characterization of the translational and transcriptional programs induced by methionine restriction through ribosome profiling and RNA-seq.


 FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism.


Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.


 Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice.


Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells.


Early feeding of rainbow trout (Oncorhynchus mykiss) with methionine-deficient diet over a 2 week period: consequences for liver mitochondria in juveniles.


Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.


Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: a study of histomorphometry, densitometry, and biomechanical properties.


Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.


Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies.


Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden.


Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.


Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.


[Methionine dependency of cancer cells: a new therapeutic approach?].


Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocysteinemia.


Dietary methionine deficiency reduces laying performances of female common ducks and impacts traits of interest of their mule ducklings.


Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.


 Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development.


Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.


Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors.


Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss).


Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice.


UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity.


Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.


Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women.


Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.


Methionine restriction effects on 11 -HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue.


Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo.


A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats.


Receptor regulation of senile phenoptosis.


Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.


Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.


 Role of beta-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction.


Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states.


Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome.


Methionine-Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice.


Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice.


Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats.


Dietary methionine restriction improves colon tight junction barrier function and alters claudin expression pattern.


Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase.


Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction.


 Expression of the aminoacyl-tRNA synthetase complex in cultured Chinese hamster ovary cells. Specific depression of the methionyl-tRNA synthetase component upon methionine restriction.


Utilization of host-derived cysteine-containing peptides overcomes the restricted sulphur metabolism of Campylobacter jejuni.


Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase.