S-Adenosyl Methionine & Cancer

Methionine adenosyltransferases in liver cancer.


S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells.


Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.


Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.


Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.


Gene methylation in gastric cancer.


IDH3α regulates one-carbon metabolism in glioblastoma.


S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.


S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.


SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.


Increased Serine and One-Carbon Pathway Metabolism by PKClambda/iota Deficiency Promotes Neuroendocrine Prostate Cancer.


mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.


Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia.


S-adenosylmethionine in liver health, injury, and cancer.


S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.


Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.


Alcohol, DNA methylation, and cancer.


Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.


S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.


Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells.


Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.


Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.

Links between Serine Biosynthesis Pathway and Epigenetics in Cancer Metabolism.


S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells.

Metabolic interactions with cancer epigenetics.

S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture.


Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells.


S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression.


Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.


Methyl donor S-adenosylmethionine (SAM) supplementation attenuates breast cancer growth, invasion, and metastasis in vivo; therapeutic and chemopreventive applications.


S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.


The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer.


S-Adenosylmethionine in cell growth, apoptosis and liver cancer.


Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study.


Methionine adenosyltransferase alpha2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.


Metabolic Intermediates in Tumorigenesis and Progression.


FOXP3 promotes colorectal carcinoma liver metastases by evaluating MMP9 expression via regulating S-adenosylmethionine metabolism.


Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors.


Mi-RNA-888-5p Is Involved in S-Adenosylmethionine Antitumor Effects in Laryngeal Squamous Cancer Cells.

L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.


S-adenosylmethionine metabolism and liver disease.


Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors.


The hepatocarcinogenic effect of methionine and choline deficient diets: an adaptation to the Warburg effect?


Reduced availability of endogenously synthesized methionine for S-adenosylmethionine formation in methionine-dependent cancer cells.


Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGFbeta1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p.

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.


Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.


Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.


Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast, and Head and Neck Cancer Treatment: Current Status of Research.


Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.


S-Adenosylmethionine and methylthioadenosine inhibit beta-catenin signaling by multiple mechanisms in liver and colon cancer.


Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.

An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis.


Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.


Subcellular localization of S-adenosyl-L-methionine:tRNA methyltransferases with aminoacyl-tRNA synthetases in human and mouse: normal and leukemic leukocytes.


S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.


The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link.


S-adenosylmethionine as a biomarker for the early detection of lung cancer.


Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry.


Structure and ligand binding of the SAM-V riboswitch.


Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).


Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review.


Acetylation of MAT IIalpha represses tumour cell growth and is decreased in human hepatocellular cancer.


Metabolism: Cancer mistunes methylation.


Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia.


Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro.


Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.


MAT2B expression correlates with poor prognosis in triple-negative breast cancer.


Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.


Therapeutic perspectives of epigenetically active nutrients.


Metabolic defects provide a spark for the epigenetic switch in cancer.


Decrease in S-adenosylmethionine synthesis by 6-mercaptopurine and methylmercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts.


Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.

5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.


Attenuation of genome-wide 5-methylcytosine level is an epigenetic feature of cutaneous malignant melanomas.


DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth.


Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.


TC2 C776G polymorphism studies in patients with oral cancer in the Polish population.


DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.


Metabolism and epigenetics: a link cancer cells exploit.

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.


S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.


Polyamine metabolism and cancer.


The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas.


NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.


Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.


Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.


Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?


Identification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy.