S-Adenosyl Methionine & Hepatic Disease

S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.


TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.


Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines.


S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.


Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.


Effects of Partially Defatted Hermetia illucens Meal in Rainbow Trout Diet on Hepatic Methionine Metabolism.


Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity.


S-adenosylmethionine in liver health, injury, and cancer.


Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol.


Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury.


Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet.


The logic of the hepatic methionine metabolic cycle.


Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury.


Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation.


S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats.


Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.


Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.


Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver.


Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice.


Age-Related Changes in Sulfur Amino Acid Metabolism in Male C57BL/6 Mice.


S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine.


[Protective effects of S-adenosylmethionine against CCl4 - and ethanol-induced experimental hepatic fibrosis].


Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.


New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells.


Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo.


Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system.


Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.


Role of methionine on epigenetic modification of DNA methylation and gene expression in animals.


Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease.


miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.


The effect of increasing concentrations of dl-methionine and 2-hydroxy-4-(methylthio) butanoic acid on hepatic genes controlling methionine regeneration and gluconeogenesis.


A new method for the assay of tissue. S-adenosylhomocysteine and S-adenosylmethione. Effect of pyridoxine deficiency on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine and polyamines in rat liver.


S-adenosylmethionine metabolism and liver disease.


Drug-induced Liver Disease in Patients with Diabetes Mellitus.


Vitamin-dependent methionine metabolism and alcoholic liver disease.


S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver.


Diminished S-adenosylmethionine biosynthesis and its metabolism in a model of hepatocellular carcinoma is recuperated by an adenosine derivative.


Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways.


Studies on acute methionine toxicity. I. Nucleolar disaggregation in guinea pig hepatic cells with methionine or ethionine and its reversal with adenine.


Metabolism of Sulfur-Containing Amino Acids in the Liver: A Link between Hepatic Injury and Recovery.


Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice.


Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.


The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.


Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations.


1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver.


Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.


Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.


Methionine adenosyltransferases in liver health and diseases.


Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes.


Treatment of nonalcoholic fatty liver disease: Where do we stand? an overview.


S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation.


Short term effect of nitrous oxide on methionine and S-adenosyl methionine concentrations.


Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.


Methionine deficiency and hepatic injury in a dietary steatohepatitis model.


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.


Parental Selenium Nutrition Affects the One-Carbon Metabolism and the Hepatic DNA Methylation Pattern of Rainbow Trout (Oncorhynchus mykiss) in the Progeny.


Acute Hepatic Failure in a Dog after Xylitol Ingestion.


Methionine Adenosyltransferase alpha1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression.


SAMe and HuR in liver physiology: usefulness of stem cells in hepatic differentiation research.


S-Adenosylmethionine Deficiency and Brain Accumulation of S-Adenosylhomocysteine in Thioacetamide-Induced Acute Liver Failure.


Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.


Regulation of S-adenosyl-L-methionine decarboxylase by 1-aminooxy-3-aminopropane: enzyme kinetics and effects on the enzyme activity in cultured cells.


Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.


Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models.


Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine.


S-Adenosylmethionine in cell growth, apoptosis and liver cancer.


Methionine metabolism in mammals. Adaptation to methionine excess.


S-Adenosylmethionine: a control switch that regulates liver function.


AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.


Catabolism and lability of S-adenosyl-L-methionine in rat liver extracts.


Transcriptional regulation of methionine adenosyltransferase 2A by peroxisome proliferator-activated receptors in rat hepatic stellate cells.


Role of methionine adenosyltransferase alpha2 and beta phosphorylation and stabilization in human hepatic stellate cell trans-differentiation.


GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.


Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency.


Maternal Consumption of Low-Isoflavone Soy Protein Isolate Confers the Increased Predisposition to Alcoholic Liver Injury in Adult Rat Offspring.


5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion.


Tunicamycin-Induced ER Stress is Accompanied with Oxidative Stress via Abrogation of Sulfur Amino Acids Metabolism in the Liver.


TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.


Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.


S-adenosylmethionine metabolism and its relation to polyamine synthesis in rat liver. Effect of nutritional state, adrenal function, some drugs and partial hepatectomy.


Methionine metabolism in mammals. The methionine-sparing effect of cystine.


S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.


Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.


Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.


Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene.


Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.


S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.


Regulation of 5-methyltetrahydrofolate synthesis.


Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.


Decarboxylated S-adenosylmethionine in mammalian cells.


Alcoholic hepatitis: a comprehensive review of pathogenesis and treatment.


Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.


Successful treatment of Yersinia pseudotuberculosis hepatitis in a cat presenting with neurological abnormalities.


The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.


Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels.


In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes.


Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.


Early effects of copper accumulation on methionine metabolism.


Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine.


Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.


NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.


Hepatic transmethylation reactions in micropigs with alcoholic liver disease.


Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression.


Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia.


Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.


NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism.


Methionine adenosyltransferase I/III deficiency: beyond the central nervous system manifestations.


Increased response of liver microsomal delta 6-desaturase activity to dietary methionine in rats.


Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency.


Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice.


Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs.


CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.


Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice.


Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows.


Metabolism of radiolabeled methionine in hepatocellular carcinoma.


Aberrant hepatic methionine metabolism and gene methylation in the pathogenesis and treatment of alcoholic steatohepatitis.


Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver.


Effects of excessive dietary methionine on oxidative stress and dyslipidemia in chronic ethanol-treated rats.


Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.


s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways.


From fatty liver to fibrosis: a tale of "second hit".


Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.


The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.


Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver.


Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure.


Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.


A synergistic, balanced antioxidant cocktail, protects aging rats from insulin resistance and absence of meal-induced insulin sensitization (AMIS) syndrome.


The effect of SAMe and betaine on Hepa 1-6, C34 and E47 liver cell survival in vitro.


Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease.


Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response.


Choline nutrition programs brain development via DNA and histone methylation.


The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats.


Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.


Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport.


Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity.


Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.


S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.