Alpha-Lipoic Acid (ALA)

alpha-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.

alpha-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion.

Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.

Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids.

Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction.

Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial.

alpha-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative conditions.

Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.

Implication of the ERK/MAPK pathway in antipsychotics-induced dopamine D2 receptor upregulation and in the preventive effects of ()-alpha-lipoic acid in SH-SY5Y neuroblastoma cells.

(R)-(+)-alpha-lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3beta pathway and suppression of NF-kappabeta-cytokines.

Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.

Novel 3-phenylcoumarin-lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease.

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.

Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling.

A Narrative Review of Complementary Nutritional Supplements for Chemotherapy-induced Peripheral Neuropathy.

Protective effects of Alpha-lipoic acid on MeHg-induced oxidative damage and intracellular Ca(2+) dyshomeostasis in primary cultured neurons.

Synthesis of new lipoic acid conjugates and evaluation of their free radical scavenging and neuroprotective activities.

Prevention of Bortezomib-Related Peripheral Neuropathy With Docosahexaenoic Acid and alpha-Lipoic Acid in Patients With Multiple Myeloma: Preliminary Data.

Neurochemical effects of the R form of alpha-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson's disease.

A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature.

Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial.

Treatment of carpal tunnel syndrome with alpha-lipoic acid.

The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review.

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.

RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level.

Optimized vinpocetine-loaded vitamin E D-alpha-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies.

Comparative evaluation of the electrophysiological, functional and ultrastructural effects of alpha lipoic acid and cyanocobalamin administration in a rat model of sciatic nerve injury.

Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.

Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology.

Epigallocatechin-3-gallate combined with alpha lipoic acid attenuates high glucose-induced receptor for advanced glycation end products (RAGE) expression in human embryonic kidney cells.

Therapeutic Effects of Rivastigmine and Alfa-Lipoic Acid Combination in the Charles Bonnet Syndrome: Electroencephalography Correlates.

Synthesis, antioxidant and Abeta anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction.

Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.

The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate and alpha-lipoic acid.

Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies.

Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.

Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid.

Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid.

Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.

Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.

Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity.

Metals, oxidative stress and neurodegenerative disorders.

Antioxidant therapies for traumatic brain injury.

Over-the-counter anti-oxidant therapies for use in multiple sclerosis: A systematic review.

Antioxidant therapies: a potential role in perinatal medicine.

Antioxidant therapy: current status and future prospects.

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease.

Ameliorative effect of a combination of vitamin E, vitamin C, alpha-lipoic acid and stilbene resveratrol on lindane induced toxicity in mice olfactory lobe and cerebrum.

Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.

Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.

Bioenergetic approaches for neuroprotection in Parkinson's disease.

Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development.

Targeting cellular energy production in neurological disorders.

Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.

Natural antioxidants and neurodegenerative diseases.

Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease.

Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners.

Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid.

Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review.

(R)-alpha-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities.

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice.

Complementary and alternative medicine for the treatment of multiple sclerosis.

Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.

(R)-alpha-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease.

Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria.

Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.

Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products.

Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.

Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism.

Influence of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, lipoic acid and L-deprenyl on the interplay between cellular redox systems.

Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.

A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment.

A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders.

Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities.

Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS.

Interaction of neuroprotective substances with human brain superoxide dismutase. An in vitro study.